HIF-1 Alpha Polyclonal Antibody, PE-Cy7 Conjugated
Cat# bs-0737R-PE-Cy7
Size : 100ul
Brand : Bioss
HIF-1 Alpha Polyclonal Antibody, PE-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-0737R-PE-Cy7 |
Product Name | HIF-1 Alpha Polyclonal Antibody, PE-Cy7 Conjugated |
Applications | WB, FCM |
Reactivity | Human, Mouse, Rat, Rabbit, Others |
Predicted Reactivity | Dog, Cow, Pig |
Specifications | |
Conjugation | PE-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human of human HIF-1 Alpha |
Immunogen Range | 341-450/826 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 3091 |
Swiss Prot | Q16665 |
Subcellular location | Cytoplasm, Nucleus |
Synonyms | HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; Member of PAS protein 1; PAS domain-containing protein 8; HIF1A |
Background | Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. |
Application Dilution | |
WB | 1:300-5000 |
FCM | 1:20-100 |