Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. Sci Rep. 9, 14746 (2019). 31611601
Tested Species Reactivity
Human, Mouse, Chicken
Predicted Species Reactivity
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit
Product Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality
Polyclonal
Host
Rabbit
Application
WB
Reconstitution and Storage
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human HIF1A
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha s
Connective tissue replacement involved in inflammatory response wound healing
22
Elastin metabolic process
11
Epithelial to mesenchymal transition
90
MRNA transcription from RNA polymerase II promoter
18
Oxygen homeostasis
24
Positive regulation of angiogenesis
241
Positive regulation of chemokine production
128
Positive regulation of chemokine-mediated signaling pathway
22
Positive regulation of endothelial cell proliferation
175
Positive regulation of epithelial cell migration
24
Positive regulation of erythrocyte differentiation
37
Positive regulation of glycolysis
82
Positive regulation of hormone biosynthetic process
13
Positive regulation of nitric-oxide synthase activity
101
Positive regulation of receptor biosynthetic process
32
Positive regulation of transcription from RNA polymerase II promoter
1210
Positive regulation of vascular endothelial growth factor receptor signaling pathway
88
Positive regulation vascular endothelial growth factor production
89
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress
19
Regulation of transforming growth factor beta2 production
24
Vascular endothelial growth factor production
11
Biological process
Name
# of Products
B-1 B cell homeostasis
1
Cardiac ventricle morphogenesis
5
Cartilage development
76
Cell differentiation
490
Cellular iron ion homeostasis
66
Cellular response to hypoxia
44
Cellular response to insulin stimulus
69
Cellular response to interleukin-1
32
Collagen metabolic process
3
Connective tissue replacement involved in inflammatory response wound healing
3
Elastin metabolic process
1
Embryonic hemopoiesis
21
Embryonic placenta development
31
Epithelial to mesenchymal transition
31
Glucose homeostasis
77
Heart looping
46
Hemoglobin biosynthetic process
6
Lactate metabolic process
4
MRNA transcription from RNA polymerase II promoter
4
Muscle cell homeostasis
18
Negative regulation of bone mineralization
15
Negative regulation of growth
9
Negative regulation of mesenchymal cell apoptosis
3
Neural crest cell migration
39
Neural fold elevation formation
1
Outflow tract morphogenesis
32
Oxygen homeostasis
6
Positive regulation of angiogenesis
97
Positive regulation of chemokine production
34
Positive regulation of chemokine-mediated signaling pathway
2
Positive regulation of endothelial cell proliferation
68
Positive regulation of epithelial cell migration
14
Positive regulation of erythrocyte differentiation
15
Positive regulation of glycolysis
15
Positive regulation of hormone biosynthetic process
6
Positive regulation of nitric-oxide synthase activity
14
Positive regulation of receptor biosynthetic process
9
Positive regulation of smooth muscle cell proliferation
67
Positive regulation of transcription from RNA polymerase II promoter
968
Positive regulation of transcription, DNA-dependent
681
Positive regulation of vascular endothelial growth factor receptor signaling pathway
20
Positive regulation vascular endothelial growth factor production
27
Regulation of catalytic activity
50
Regulation of gene expression
75
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress
8
Regulation of transcription, DNA-dependent
1734
Regulation of transforming growth factor beta2 production
5
Response to glucose stimulus
72
Response to hypoxia
205
Response to muscle activity
7
Signal transduction
1058
Vascular endothelial growth factor production
1
Cellular components
Name
# of Products
Cytoplasm
4549
Microtubule-based flagellum
17
Nucleolus
1179
Nucleus
4914
Transcription factor complex
286
Protein function
Name
# of Products
Histone acetyltransferase binding
69
Histone deacetylase binding
181
Hsp90 protein binding
77
Protein binding
12191
Protein heterodimerization activity
1132
Protein kinase binding
1101
Sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
418
Sequence-specific DNA binding
1803
Sequence-specific DNA binding transcription factor activity
2776
Signal transducer activity
1270
Transcription factor binding
934
Transcription regulatory region DNA binding
657
What is the species homology for "HIF1A Antibody - middle region (ARP38054_P050)"?
The tested species reactivity for this item is "Human, Mouse, Chicken". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit".
How long will it take to receive "HIF1A Antibody - middle region (ARP38054_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
What buffer format is "HIF1A Antibody - middle region (ARP38054_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.". Additional format options may be available. For more information please contact info@avivasysbio.com.
What are other names for "HIF1A Antibody - middle region (ARP38054_P050)"?
This target may also be called "HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF-1-alpha" in publications.
What is the shipping cost for "HIF1A Antibody - middle region (ARP38054_P050)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
What is the guarantee for "HIF1A Antibody - middle region (ARP38054_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
Can I get bulk pricing for "HIF1A Antibody - middle region (ARP38054_P050)"?
You can get bulk pricing for this item by going here.
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "93kDa". Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.
What protocols are available for "HIF1A Antibody - middle region (ARP38054_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
What are positive controls for "HIF1A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What are negative controls for "HIF1A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
What other proteins interact with "HIF1A"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
What biological processes are associated with "HIF1A"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
What cellular components are associated with "HIF1A"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
What protein functions are associated with "HIF1A"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
HIF1A Antibody - N-terminal region (ARP30572_P050)
Catalog #: ARP30572_P050
Species Tested: Human
Application: IHC, WB
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Phone : +1 850 650 7790