Human MIP3a (Macrophage Inflammatory Protein 3 Alpha) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	CCL20
Gene ID:	6364
Uniprot ID:	CCL20_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Post Translational Modifications	C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Function	Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213.
Protein Name	C-C Motif Chemokine 20 Beta-Chemokine Exodus-1 Cc Chemokine Larc Liver And Activation-Regulated Chemokine Macrophage Inflammatory Protein 3 Alpha Mip-3-Alpha Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70
Database Links	Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Secreted
Alternative ELISA Names	C-C Motif Chemokine 20 ELISA kit Beta-Chemokine Exodus-1 ELISA kit Cc Chemokine Larc ELISA kit Liver And Activation-Regulated Chemokine ELISA kit Macrophage Inflammatory Protein 3 Alpha ELISA kit Mip-3-Alpha ELISA kit Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 ELISA kit CCL20 ELISA kit LARC ELISA kit MIP3A ELISA kit SCYA20 ELISA kit
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Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance