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> Hydroxychloroquine sulfate [747-36-4]

Hydroxychloroquine sulfate [747-36-4]

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Cat# 10-1379-50mg

Size : 50mg

Brand : Focus Biomolecules

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Hydroxychloroquine sulfate | Autophagy inhibitor

CAS:
747-36-4
Catalog Number:
10-1379
Activity:
Antimalarial/Autophagy inhibitor
Chemical Names:
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinolone sulfate
Molecular Weight:
433.96
Molecular Formula:
C18H26ClN3O·H2SO4
Solubility:
Soluble in Water (40 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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250 mg$100.00
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Hydroxychloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy.3 Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells.4 Hydroxychloroquine sulfate has been used to treat alopecia successfully5 and is a clinically useful antimalaria agent. Cell permeable and active in vivo.

References/Citations
1) Boya et al. (2005), Inhibition of macroautophagy triggers apoptosis; Mol. Cell Biol., 25 1025
2) Xie et al. (2013), Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma; PLoS One, 8 e55096
3) Pan et al. (2011), Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy; Clin. Cancer Res., 150 3248
4) Jeong et al. (2002), Chloroquine decreases cell-surface expression of tumor necrosis factor receptors in human histiocytic U-937 cells; Immunology, 105 83
5) Stephan et al. (2013), Successful treatment of alopecia totalis with hydroxychloroquine: report of 2 cases; J. Am. Acad. Dermatol., 68 1048

CAS:
747-36-4
Catalog Number:
10-1379
Activity:
Antimalarial/Autophagy inhibitor
Chemical Names:
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinolone sulfate
Molecular Weight:
433.96
Molecular Formula:
C18H26ClN3O·H2SO4
Solubility:
Soluble in Water (40 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Hydroxychloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy.3 Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells.4 Hydroxychloroquine sulfate has been used to treat alopecia successfully5 and is a clinically useful antimalaria agent. Cell permeable and active in vivo.

References/Citations
1) Boya et al. (2005), Inhibition of macroautophagy triggers apoptosis; Mol. Cell Biol., 25 1025
2) Xie et al. (2013), Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma; PLoS One, 8 e55096
3) Pan et al. (2011), Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy; Clin. Cancer Res., 150 3248
4) Jeong et al. (2002), Chloroquine decreases cell-surface expression of tumor necrosis factor receptors in human histiocytic U-937 cells; Immunology, 105 83
5) Stephan et al. (2013), Successful treatment of alopecia totalis with hydroxychloroquine: report of 2 cases; J. Am. Acad. Dermatol., 68 1048