ELISA: The antibody (1:500,000 diluted) can detect the TREK-1 peptide coated on ELISA plate at 100ng/well. Western blot: Dilute approx. 1:3,000 to detect the 47kDa TREK-1 in Jurkat cell extract.
Reactivity
Human
Antibody Host
Rabbit
Clonality
Polyclonal
Immunogen
A synthetic peptide derived from the amino sequence 4-14 of human TREK-1, conjugated with KLH
Specificity
This antibody reacts with the 47kDa TREK-1 in Jurkat cell extract.
Restore with double distilled water to adjust the final concentration to 1.00 mg/ml.
Purification
Protein G affinity
Conjugation
Unconjugated
Storage
Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability
Shelf life: one year from despatch.
Shipping
Ambient
Gene Name
potassium two pore domain channel subfamily K member 2
TWIK-related potassium channel 1(TREK-1), also known as K2P2.1, is a two pore domain gated potassium channel that is involved with pain reception. TREK-1 is highly expressed in small sensory neurons and is extensively colocalized with TRPV1. TREK-1 is sensitive to noxious stimuli including extracellular pH, temperature, mechanical force, osmotic pressure and other stimuli. TREK-1 is one of the targets for pain mediator and anaesthesia drug.
Synonyms
KCNK2, TREK, TREK1, Potassium channel subfamily K member 2, Two pore potassium channel TPKC1
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