KISS1 Polyclonal Antibody, PE-Cy7 Conjugated
Cat# bs-0749R-PE-Cy7
Size : 100ul
Brand : Bioss
KISS1 Polyclonal Antibody, PE-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-0749r-pe-cy7-100ul |
Product Name | KISS1 Polyclonal Antibody, PE-Cy7 Conjugated |
Applications | WB |
Specificity | This antibody detects Kisspeptin-10 region of Kisspeptin. |
Reactivity | Human, Mouse, Rat |
Predicted Reactivity | Cow, Sheep |
Specifications | |
Conjugation | PE-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human KISS1 |
Immunogen Range | 81-145/145 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 3814 |
Swiss Prot | Q15726 |
Subcellular location | Secreted |
Synonyms | HH13; KiSS-1; Metastasis-suppressor KiSS-1; Kisspeptin-1; KISS1; PP598 |
Background | Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-1 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-1, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-1 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. |
Application Dilution | |
WB | 1:300-5000 |