Paclitaxel (Taxol) [33069-62-4]
Cat# A4393-50mg
Size : 50mg
Brand : APExBIO Technology
Contact local distributor :
Phone : +1 850 650 7790
Paclitaxel (Taxol)
Paclitaxel is a novel antineoplastic agent, which was discovered in a screen of extracts of thousands of plants and natural products for antineoplastic activity by a National Cancer Institute program. Alought it functions as a mitotic inhibitor like vinca alkaloids, paclitaxel promotes the polymerization of tubulin instead of inducing the disassembly of microtubules, which inhibits the microtubules disassembly and promotes the formation of excessively stable, dysfunctional microtubules. Paclitaxel has exhibited antitumor activity against a broad spectrum of human cancers, including ovarian, breast, head and neck, and lung cancer, in a large number of studies.
Reference
Ross C. Donehower. The clinical development of paclitaxel: a successful collaboration of academia, industry and the National cancer Institute. STEM CELLS 1996;14:25-28
- 1. Lei Li, Shuangshuang Sun, et al. "Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation." Research Square. 26 Sep, 2024
- 2. Sanjeev Raghuwanshi, Xu Zhang, et al. "Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies." Cell Death Discov. 2024 May 2;10(1):211. PMID: 38697979
- 3. Catherine S Snyder, Taylor Repetto, et al. "Co-Delivery Polymeric Poly (Lactic-Co-Glycolic Acid)(PLGA) Nanoparticles to Target Cancer Stem-Like Cells." Methods Mol Biol. 2024:2777:191-204. PMID: 38478345
- 4. Shengli Dong, Margarite D Matossian, et al. "Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy." Sci Rep. 2023 Jul 22;13(1):11843. PMID: 37481672
- 5. Aeson Chang, Edoardo Botteri, et al. "Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer." Sci Transl Med. 2023 Apr 26;15(693):eadf1147. PMID: 37099632
- 6. Schwartz, Hannah, et al. "In vitro Methods to Better Evaluate Drug Responses in Cancer." UMass Chan Medical School. September 8, 2022.
- 7. Darya A. Stepanova, Vladislava A. Pigareva, et al. "Ultrasonic Film Rehydration Synthesis of Mixed Polylactide Micelles for Enzyme-Resistant Drug Delivery Nanovehicles." Polymers (Basel). 2022 Sep 25;14(19):4013. PMID: 36235958
- 8. Shengli Dong, Hassan Yousefi, et al. "Ceritinib is a novel triple negative breast cancer therapeutic agent." Mol Cancer. 2022 Jun 29;21(1):138. PMID: 35768871
- 9. Prateek Bhardwaj, Vikram Gota, et al. "Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy." J Control Release. 2022 Mar;343:288-302. PMID: 35101477
- 10. Mikhail S. Chesnokov, Marianna Halasi, et al. "Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells." Cell Death Dis. 2021 Jul 14;12(7):704. PMID: 34262016
- 11. Anirban Roychowdhury, Mayur Jondhale, et al. "Landscape of toll-like receptors expression in tumor microenvironment of triple negative breast cancer (TNBC): Distinct roles of TLR4 and TLR8." Gene. 2021 Aug 5;792:145728. PMID: 34022297
- 12. Catherine Suzanne Snyder. "Polymer Nanoparticle Design for Ovarian Cancer Therapies." University of Michigan 2021.
- 13. Juanwen Lian, Tao Hua, et al. "Interleukin-1β weakens paclitaxel sensitivity through regulating autophagy in the non-small cell lung cancer cell line A549." Exp Ther Med. 2021 Apr;21(4):293. PMID: 33717236
- 14. Chu xue, Si-Xue Liu, et al. "Corydalis Saxicola Bunting Total Alkaloids Inhibits Paclitaxel-Induced Peripheral Neuropathy By Regulating PKCε-TRPV1 and p38 MAPK-TRPV1 Signaling Pathways." Research Square. doi.org/10.21203/rs.3.rs-332970/v1.
- 15. Yongman Liu, Jianye Wang, et al. "Quantifying 3D cell–matrix interactions during mitosis and the effect of anticancer drugs on the interactions." Nano Research. ISSN 1998-0124 CN 11-5974/O4.
- 16. Shahbandi A, Rao SG, et al. "BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer." Cell Death Differ. 2020;10.1038/s41418-020-0564-6. PMID: 32457483
- 17. Gamache JE, Kemper L, et al. "Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice." J Neurosci. 2019 Nov 4. pii: 1256-19. PMID: 31685653
- 18. Tonnessen-Murray CA, Frey WD, et al. "Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival." J Cell Biol. 2019 Sep 17. pii: jcb.201904051. PMID: 31530580
- 19. Chung HK, Zou X, et al. "A compact synthetic pathway rewires cancer signaling to therapeutic effector release." Science. 2019 May 3;364(6439). PMID: 31048459
- 20. Zhang Y, Xia F, et al. "miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2." J Exp Clin Cancer Res. 2019 Jan 21;38(1):26. PMID: 30665445
- 21. Deng Y, Li F, et al. "Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition." Mol Carcinog. 2018 Jun;57(6):807-814. PMID: 29500880
- 22. Zina Hamoudi , Thang Manh Khuong, et al. "A fruit fly model for studying paclitaxel-induced pain [version 1;referees: awaiting peer review]" F1000Research 23 Jan 2018, 7:99.
- 23. Yu Wang，Zhenxin Zhu, et al. "The effect of phenotypic conditioned medium on the proliferation of BGC823 in human gastric cancer cell line." Academic Journal of Second Military Medical University,Dec.2017,Vol.38,No.12.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 853.91 |
| Cas No. | 33069-62-4 |
| Formula | C47H51NO14 |
| Synonyms | Taxol |
| Solubility | ≥85.6 mg/mL in DMSO; insoluble in H2O; ≥31.6 mg/mL in EtOH with ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | O=C(N[C@H]([C@H](C(O[C@H]1C[C@]2(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]3(C)[C@]([C@@](CO4)(OC(C)=O)[C@H]4C[C@@H]3O)(18)[C@@H]2OC(C5=CC=CC=C5)=O)=O)=C1C)=O)O)C6=CC=CC=C6)C7=CC=CC=C7 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment: [1] | |
| Cell lines | Human arterial endothelial (haEC) cells |
| Preparation method | The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. |
| Reaction Conditions | 1 μM, 24 hours |
| Applications | Nonstop and single-dose (24-hour) applications were performed and cell proliferation was determined after 6 days by use of cell counting, BrdU-ELISA and MTT tests. A dose-dependent, significant growth inhibition occurred at high concentrations (0.01 to 1.0 μmol/L), whereas lower paclitaxel doses (0.1 to 1.0 nmol/L) did not inhibit haEC growth significantly. Furthermore, no unspecific cytotoxic effects were observed within this concentration range. |
| Animal experiment: [2] | |
| Animal models | Female CB17 SCID mice |
| Dosage form | Intravenous injection, 12.5 mg per kg body weight |
| Applications | In mice treated with paclitaxel, the interface between tumor and dermal graft was ill defined, and small groups of tumor cells were seen within the human dermis and were surrounded by dilated vessels. Quantification of vessel cross-sections confirmed the histologic impression: numbers of vessels per high power field were significantly less in LP-treated mice compared with paclitaxel- and liposome-treated mice, respectively. |
| Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
| References: [1] Axel D I, Kunert W, Göggelmann C, et al. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation, 1997, 96(2): 636-645. [2] Kunstfeld R, Wickenhauser G, Michaelis U, et al. Paclitaxel encapsulated in cationic liposomes diminishes tumor angiogenesis and melanoma growth in a “humanized” SCID mouse model. Journal of investigative dermatology, 2003, 120(3): 476-482. | |
| Description | Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. | |||||
| Targets | Microtubule (human endothelial cells) | |||||
| IC50 | 0.1 pM | |||||
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