WNK1 Antibody
Cat# OAAN00903-100UL
Size : 100ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
WNK1 Antibody (OAAN00903)
| Datasheets/Manuals | Printable datasheet for WNK1 Antibody (OAAN00903) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Application | ELISA, ICC, IF, WB |
| Reconstitution and Storage | Store at -20C. Avoid repeated freeze/thaw cycles. |
| Immunogen | WNK1 |
| Purification | Affinity purified against immunogen |
| Application Info | WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200 |
| Gene Symbol | WNK1 |
|---|---|
| Gene Full Name | WNK lysine deficient protein kinase 1 |
| Alias Symbols | erythrocyte 65 kDa protein, HSAN2, HSN2, KDP, Kinase deficient protein, p65, PPP1R167, PRKWNK1, prostate-derived sterile 20-like kinase, Protein kinase lysine-deficient 1, protein kinase with no lysine 1, protein phosphatase 1, regulatory subunit 167, PSK, serine/threonine-protein kinase WNK1, serine/threonine-protein kinase WNK1 1, serine/threonine-protein kinase WNK1 2. |
| NCBI Gene Id | 65125 |
| Protein Name | Serine/threonine-protein kinase WNK1 |
| Description of Target | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). |
| Uniprot ID | Q9H4A3 |
| Protein Accession # | NP_001171914.1 |
| Nucleotide Accession # | NM_001184985.1 |
| Molecular Weight | 251kDa |