Mitofusin 1 (MFN1) Rabbit Polyclonal Antibody
Referencia TA336806
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Mitofusin 1 (MFN1) Rabbit Polyclonal Antibody
SKU
TA336806
Rabbit Polyclonal Mitofusin 1 Antibody
| Product Data | |
| Application | ICC/IF, IHC, WB |
|---|---|
| Application | Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin: 1:100, Western Blot |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | A genomic peptide made to an N-terminal region of human Mitofusin-1 (within residues 5-100). [Swiss-Prot Q8IWA4] |
| Buffer | PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Concentration | lot specific |
| Purification | Immunogen affinity purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | mitofusin 1 |
| Database Link | |
| Background | Mitochondria are dynamic organelles that continuously divide and fuse, and their dynamics/distribution is critical for their role in bioenergetics and cell survival. Mitochondrial fusion process is mediated by mitofusin 1 (MFN1) and mitofusin 2 (MFN2) proteins in the outer membrane as well as OPA1 in the inner mitochondrial membrane. MFN1 is an essential transmembrane GTPase critical to mitochondrial fusion; acts independently of the cytoskeleton, and its overexpression induces formation of mitochondrial networks. MFN1 forms homo-/-heteromultimers (with MFN2), and the multimerization has been proposed to be essential for mitochondrion fusion. MFN1 interacts with VAT1 and is ubiquitinated by MARCH5. A mutation in the GTPase domain disrupts the mitochondrial fusion activity of MFN1/MFN2 and loss of MFN1/2 leads to mitochondrial dysfunction mediated embryonic lethality in mice. MFN proteins have been reported to regulate mitochondrial membrane potential, while silencing of MFN1/2 resulte in mitochondrial fragmentation and increased apoptotic sensitivity. |
| Synonyms | hfzo1; hfzo2 |
| Note | This MFN1 antibody is useful for Immunocytochemistry/Immunofluorescence, and IHC-P. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Western Blot was reported in scientific literature. |
| Reference Data | |
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