General Info
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human/Rhesus/Bovine/Cynomolgus Monkey/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD62L is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | FMC46 |
| Conjugation: | PE |
| Isotype: | IgG2b |
| Formulation: | PBS with 0.09% sodium azide and 1% BSA, 5%sucrose |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Immunogen: | PHA stimulated lymphoblasts |
Description
| Background | Mouse anti Human CD62L antibody, clone FMC46 recognizes human CD62L, also known a L-selectin, a 74-95 kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes.CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naïve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains.The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance