Anti-HSP27 Monoclonal Antibody (Clone : 8A7) - Alkaline Phosphatase(Discontinued)
Figure1 : Mouse Anti-Hsp27 Antibody [8A7] used in Immunohistochemistry (IHC) on Rat embryo somites
embalaje : 100ug
Figure1 : Mouse Anti-Hsp27 Antibody [8A7] used in Immunohistochemistry (IHC) on Rat embryo somites
Amount : | 100 µg |
Isotype : | Mouse IgG1 Kappa |
Purification : | Protein G Purified |
Content : | PBS, 50% glycerol, 0.09% sodium azide |
Storage condition : | Store the antibody at 4°C |
WB (1:5000), ICC/IF (1:200), IHC (1:100); optimal dilutions for assays should be determined by the user.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Cytoplasm, Nucleus, Cytoplasm |
Post transnational modification: | Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925). |
Tissue Specificity: | Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. |
BioGrid: | 109547. 439 interactions. |
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