Apilimod (mesylate) [870087-36-8]
Referencia HY-14644A-10mg
embalaje : 10mg
Marca : MedChemExpress
Descripciòn | ||||||
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IC50 & Target[1][2] |
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In Vitro |
Apilimod inhibits IFN-γ production induced by either IFN-γ/SAC or SAC in human PBMCs, with an IC50 of approximately 20 nM. Apilimod show some inhibition against IFN-γ/SAC-induced TNF-α and ConA-induced IL-5 from human PBMCs at high concentrations, but no suppressive effect against IL-1β, IL-2, IL-4, IL-8, and IL-18 in all cultures tested. The p35 and p40 promoter-driven luciferase activities are significantly induced after stimulation with IFN-γ/LPS or IFN-γ/SAC, and are completely suppressed by 100 nM Apilimod[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |