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> Concanavalin A [11028-71-0]

Concanavalin A [11028-71-0]

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Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury.

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Concanavalin A Estructura química

Concanavalin A Estructura química

No. CAS : 11028-71-0

This product is a controlled substance and not for sale in your territory.

Based on 2 publication(s) in Google Scholar

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Descripciòn

Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury[1][3].

In Vivo

Concanavalin A (20 mg/kg; i.v.) induces autoimmune hepatitis in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, 20 g Male Balb/c mice[3]
Dosage: 20 mg/kg
Administration: I.v.
Result: Increased the ALT and AST levels after 8 hours.
No. CAS

11028-71-0

Appearance

Solid

Color

White to light yellow

SMILES

[Concanavalin A]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 8.33 mg/mL (Need ultrasonic)

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Pureza y Documentación

SDS (418 KB)

COA (243 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. Li W, et, al. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem Biophys Res Commun. 2011 Oct 22;414(2):282-6.  [Content Brief]

    [2]. Cantelli A, et, al. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852.  [Content Brief]

    [3]. Zhou Y, et al. The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice. Gastroenterol Res Pract. 2015;2015:506390.  [Content Brief]

  • [1]. Li W, et, al. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem Biophys Res Commun. 2011 Oct 22;414(2):282-6.

    [2]. Cantelli A, et, al. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852.

    [3]. Zhou Y, et al. The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice. Gastroenterol Res Pract. 2015;2015:506390.

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Concanavalin A Related Classifications

  • Inflammation/Immunology Infection Cancer
  • Cancer Immunotherapy Cancer Metabolism and Metastasis
  • Anti-infection Apoptosis
  • Antibiotic Apoptosis
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Concanavalin A11028-71-0AntibioticApoptosismannoseglucoseplant lectinjack beanprogrammed cell deathInhibitorinhibitorinhibit

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