Gamma-glutamylcysteine [636-58-8]
Referencia HY-113402-25mg
embalaje : 25mg
Marca : MedChemExpress
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Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels.
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Gamma-glutamylcysteine Estructura química
No. CAS : 636-58-8
Based on 1 publication(s) in Google Scholar
Other Forms of Gamma-glutamylcysteine:
- Gamma-glutamylcysteine TFA In-stock
| Descripciòn |
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels[1]. |
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| IC50 & Target |
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| In Vitro |
Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Peso molecular |
250.27 |
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| Fòrmula |
C8H14N2O5S |
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| No. CAS |
636-58-8 |
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| Appearance |
Solid |
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| Color |
White to off-white |
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| SMILES |
SC[C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O |
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| Structure Classification |
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| Initial Source |
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| Envío | Room temperature in continental US; may vary elsewhere. |
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| Almacenamiento |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Solvente y solubilidad |
In Vitro:
H2O : 100 mg/mL (399.57 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Referencias |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 3.9957 mL | 19.9784 mL | 39.9568 mL | 99.8921 mL |
| 5 mM | 0.7991 mL | 3.9957 mL | 7.9914 mL | 19.9784 mL | |
| 10 mM | 0.3996 mL | 1.9978 mL | 3.9957 mL | 9.9892 mL | |
| 15 mM | 0.2664 mL | 1.3319 mL | 2.6638 mL | 6.6595 mL | |
| 20 mM | 0.1998 mL | 0.9989 mL | 1.9978 mL | 4.9946 mL | |
| 25 mM | 0.1598 mL | 0.7991 mL | 1.5983 mL | 3.9957 mL | |
| 30 mM | 0.1332 mL | 0.6659 mL | 1.3319 mL | 3.3297 mL | |
| 40 mM | 0.0999 mL | 0.4995 mL | 0.9989 mL | 2.4973 mL | |
| 50 mM | 0.0799 mL | 0.3996 mL | 0.7991 mL | 1.9978 mL | |
| 60 mM | 0.0666 mL | 0.3330 mL | 0.6659 mL | 1.6649 mL | |
| 80 mM | 0.0499 mL | 0.2497 mL | 0.4995 mL | 1.2487 mL | |
| 100 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9989 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Gamma-glutamylcysteine Related Classifications
- Inflammation/Immunology
- Metabolic Enzyme/Protease
- Endogenous Metabolite