Human ADRbK1 (Adrenergic Receptor Beta Kinase 1) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	GRK2
Gene ID:	156
Uniprot ID:	ARBK1_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in peripheral blood leukocytes.
Post Translational Modifications
Function	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.
Protein Name	Beta-Adrenergic Receptor Kinase 1 Beta-Ark-1 G-Protein Coupled Receptor Kinase 2
Database Links	Reactome: R-HSA-111933 Reactome: R-HSA-416476 Reactome: R-HSA-418555 Reactome: R-HSA-5635838 Reactome: R-HSA-8856825
Cellular Localisation	Cytoplasm Cell Membrane Postsynapse Presynapse
Alternative ELISA Names	Beta-Adrenergic Receptor Kinase 1 ELISA kit Beta-Ark-1 ELISA kit G-Protein Coupled Receptor Kinase 2 ELISA kit GRK2 ELISA kit ADRBK1 ELISA kit BARK ELISA kit BARK1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance