Human ATP citrate lyase (ACLY) activation kit by CRISPRa
Referencia GA100035
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Human ATP citrate lyase (ACLY) activation kit by CRISPRa
SKU
GA100035
ACLY CRISPRa kit - CRISPR gene activation of human ATP citrate lyase
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | ACLY |
| Locus ID | 47 |
| Components | GA100035G1, ATP citrate lyase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100035G2, ATP citrate lyase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100035G3, ATP citrate lyase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001096, NM_001303274, NM_001303275, NM_198830 |
| UniProt ID | P53396 |
| Synonyms | ACL; ATPCL; CLATP |
| Summary | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN400508 | ACLY - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.