Mouse Anti Human Glycophorin A (type M & type N)

Referencia ant-231-1mg

embalaje : 1mg

Marca : Prospec

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Catalogue number

ANT-231

Type

Mouse Anti Human Monoclonal Antibody.

Synonyms

Glycophorin-A, MN sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GPA, MN, MNS, GPSAT, GPErik, HGpMiV, HGpMiXI, HGpSta(C).

Introduction

Glycophorins A & B (GYPA &GYPB) are the main sialoglycoproteins of the human erythrocyte membrane which carry the antigenic determinants for the MN and Ss blood groups. Along with the M or N and S or s antigens which normally occur in all populations, approximately 40 related variant phenotypes were identified. These variants comprise all the variants of the Miltenberger complex and some isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. GYPA is significant for the function of SLC4A1 and is necessary for high activity of SLC4A1. GYPA is involved in translocation of SLC4A1 to the plasma membrane. GYPA is also a receptor for: the influenza virus, Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans and is also a receptor for Hepatitis A virus (HAV).

Clone

NYRhGlycophorinA.

Immunogen

r.Human GlycophorinA.

Ig Subclass

Mouse IgG1.

Purification Method

Protein A column.

Formulation

1mg/ml in PBS (after reconstitution).

Shipping Conditions

Antibody is shipped lyophilized at ambient temperature.

Storage Procedures

In lyophilized form, for long periods, store at 4 class="topDotted">Solubility
Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Titer

By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).

Safety Data Sheet

Applications

Western Blot, imunohistochemistry, flow cytometry. For WB use 1-10 class="topDotted">Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.