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> Recombinant Human TNF-Like 1/TL1A/TNFSF15

Recombinant Human TNF-Like 1/TL1A/TNFSF15

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Referencia C038-1mg

embalaje : 1mg

Marca : Bon Opus Biosciences

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Teléfono : +1 850 650 7790

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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
O95150-2
Species
Human
Expression System
E.coli
Target Sequence
Met1-Leu192
Tag
tag free
Formulation
Lyophilized from a 0.2 um filtered solution of 20mM PB, 250mM NaCl, pH 7.5.
Packaging
Ambient
Background
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TNFSF15; TL1; VEGI
Alternative Names
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Citation
NA
Activity