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> Reuterin [2134-29-4]

Reuterin [2134-29-4]

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Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates.

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Reuterin Estructura química

Reuterin Estructura química

No. CAS : 2134-29-4

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Descripciòn

Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates[1][2].

In Vitro

Reuterin is water soluble, effective in a wide range of pH, resistant to proteolytic and lipolytic enzymes and has been therefore studied as a food preservative or auxiliary therapeutic agent. Reuterin is a potent antimicrobial with high activity against a broad panel of C. jejuni and C. coli isolates[1].
Reuterin is produced by certain strains of L. reuteri during anaerobic fermentation of glycerol and has a broad-spectrum antimicrobial property against enteric pathogens and intestinal bacteria[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reuterin Related Antibodies
Ensayo clínico
Peso molecular

74.08

Fòrmula

C3H6O2
No. CAS

2134-29-4
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=CCCO
Structure Classification
  • Ketones, Aldehydes, Acids
Initial Source
  • Microorganisms

Lactobacillus reuteri
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

H2O : 250 mg/mL (3374.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.4989 mL 67.4946 mL 134.9892 mL
5 mM 2.6998 mL 13.4989 mL 26.9978 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (1349.89 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.59%

COA (242 KB) GC (236 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. Schaefer L, et al. The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. Microbiology (Reading). 2010;156(Pt 6):1589-1599.  [Content Brief]

    [2]. Asare PT, et al. Reuterin Demonstrates Potent Antimicrobial Activity Against a Broad Panel of Human and Poultry Meat Campylobacter spp. Isolates. Microorganisms. 2020;8(1):78. Published 2020 Jan 6.  [Content Brief]

  • [1]. Schaefer L, et al. The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. Microbiology (Reading). 2010;156(Pt 6):1589-1599.

    [2]. Asare PT, et al. Reuterin Demonstrates Potent Antimicrobial Activity Against a Broad Panel of Human and Poultry Meat Campylobacter spp. Isolates. Microorganisms. 2020;8(1):78. Published 2020 Jan 6.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 13.4989 mL 67.4946 mL 134.9892 mL 337.4730 mL
5 mM 2.6998 mL 13.4989 mL 26.9978 mL 67.4946 mL
10 mM 1.3499 mL 6.7495 mL 13.4989 mL 33.7473 mL
15 mM 0.8999 mL 4.4996 mL 8.9993 mL 22.4982 mL
20 mM 0.6749 mL 3.3747 mL 6.7495 mL 16.8736 mL
25 mM 0.5400 mL 2.6998 mL 5.3996 mL 13.4989 mL
30 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
40 mM 0.3375 mL 1.6874 mL 3.3747 mL 8.4368 mL
50 mM 0.2700 mL 1.3499 mL 2.6998 mL 6.7495 mL
60 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
80 mM 0.1687 mL 0.8437 mL 1.6874 mL 4.2184 mL
100 mM 0.1350 mL 0.6749 mL 1.3499 mL 3.3747 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Reuterin Related Classifications

  • Infection
  • Anti-infection
  • Bacterial
Help & FAQs

Keywords:

Reuterin2134-29-43-Hydroxypropionaldehyde 3-HydroxypropanalBacterialantimicrobialanaerobicmetabolismglycerolGramInhibitorinhibitorinhibit

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