Stemolecule A83-01

Referencia 04-0014-10

embalaje : 10mg

Marca : ReproCELL

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Stemolecule™ A83-01

04-0014 / 04-0014-10

Brand: Stemolecule

A83-01 is a selective inhibitor of the transforming growth factor-beta (TGF-β) type I receptor ALK5, the Activin/Nodal receptor ALK4, and the nodal receptor ALK71.

CAS Number: 909910-43-6
Alternate Name(s):
  • A-83-01
  • A 83-01
  • 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Note: shown do not include shipping and handling charges.

Product Information

04-0014 Specifications Sheet
  • 04-0014-10 Specifications Sheet
  • Safety Data Sheets:

    Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., Node, M., and Imamura, T. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factorβ. Cancer Sci 96: 791-800 (2005).
  • Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., Hao, E., Hayek, A., Deng, H., and Ding, S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4: 16-19 (2009).
  • Additional Publications

    • Ai Z; Xiang X; Xiang Y; Szczerbinska I; Qian Y; Xu X; Ma C; Su Y; Gao B; Shen H; bin Ramli MN; Chen D; Liu Y; Hao J-j; Ng HH; Zhang D; Chan Y-S; Liu W; Liang H. Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency. Cell Reports 40:111240 (2022).
    • Tsukamoto M; Kimura K; Yoshida T; Sugiura K; Hatoya S. Canine induced pluripotent stem cells efficiently differentiate into definitive endoderm in 3D cell culture conditions using high-dose activin A. Regen Therapy 21:502 (2022).
    • Weiß F; Holthaus D; Kraft M; Klotz C; Schneemann M; Schulzke JD; Krug SM. Human duodenal organoid-derived monolayers serve as a suitable barrier model for duodenal tissue. Ann New York Acad Sci 1515:155 (2022).
    • Mao Z; Li Y; Huang L; Chen Y; Luo H; Zhang S; Chen H; . Generation of an induced pluripotent stem cell line HUSTTJi001-A from a Moyamoya disease patient with RNF213 gene mutation. Stem Cell Res 57:102575 (2021).
    • Kimura K; Tsukamoto M; Tanaka M; Kuwamura M; Ohtaka M; Nishimura K; Nakanishi M; Sugiura K; Hatoya S. Efficient Reprogramming of Canine Peripheral Blood Mononuclear Cells into Induced Pluripotent Stem Cells. Stem Cells Develop in press:https://doi.org/10.1089/scd.2020.0084 (2020).
    • Wang T; Li J; Xiao Y; Fu B; Wang P; Bai X; Cai G; Chen X; Li Q. Generation of induced pluripotent stem cell PLAFMCi002-A derived from peripheral blood mononuclear cells of polycystic kidney disease patient with PKD1 mutation. Stem Cell Res 49:102039 (2020).
    • Wang S-H; Wang X-P. Generation of an induced pluripotent stem cell (iPSC) line (THSJTUi001-A) from a Wilson's disease patient harboring a homozygous Arg778Leu mutation in ATP7B gene. Stem Cell Res 49:102050 (2020).
    • Liu WM; Cheng RR; Niu ZR; Chen AC; Ma MY; Li T; Chiu PC; Pang RT; Lee YL; Ou JP ; Yao YQ; Yeung WSB. Let-7 derived from endometrial extracellular vesicles is an important inducer of embryonic diapause in mice. Sci Adv 6:eaaz7070 (2020).
    • Shan H; Ye J; Zhuang T; TIanRui H; HaiPing X; ShengSheng Z; XinYue H; HanYu L; Lun W; ShuYang Z. Establishment of an induced pluripotent stem cell line PUMCHi004-A from a hereditary transthyretin amyloid cardiomyopathy patient with transthyretin (TTR) p.Asp38Asn mutation. Stem Cell Res :102022 (2020).
    • Shen H; Ye J; Ping XH; Yue HX; Yang ZS. Establishment of an induced pluripotent stem cell line from a patient with hereditary transthyretin amyloidosis carrying transthyretin (TTR) mutation p.Phe53Val. Stem Cell Res https://doi.org/10.1016/j.scr.2020.101940: (2020).
    • Long P; Liu Z; Wu B; Chen J; Sun C; Wang F; Huang Y; Chen H; Li Q; Ma Y. Generation of an induced pluripotent stem cell line from chorionic villi of a Patau syndrome spontaneous abortion. Stem Cell Res 45:101789 (2020).
    • Ghatak S; Dolatabadi N; Trudler D; Zhang XT; Wu Y; Mohata M; Ambasudhan R; Talantova M; Lipton SA. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control. eLife 8:e50333 (2019).
    • Vahdat S; Pahlavan S' Mahmoudi E; Barekat M; Ansari H; Bakhshandeh B; Aghdami N; Baharvand H. Expansion of Human Pluripotent Stem Cell-derived Early Cardiovascular Progenitor Cells by a Cocktail of Signaling Factors. Sci Rep 9:16006 (2019).
    • Peng L; Zhou Y; Xu W; Jiang M; Li H; Long M; Liu W; Liu J; Zhao X; Xiao Y. Generation of Stable Induced Pluripotent Stem-like Cells from Adult Zebra Fish Fibroblasts. Int J Biol Sci 15:2340 (2019).
    • Harmanto Y; Maki T; Yakagi Y; Miyamoto S; Takahashi J. Xeno‐free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells. J Neuro Res 2019:1-18 (2019).
    • Wang L; De SOlis AJ; Goffer Y; Birkenback KE; Engle SE; Tanis R; Levenson JM; Lu X; Rausch R: Purohit M; Lee J-Y; Tan J; De Rosa MC; DOege CA; Aaron HL; Martins G; Brüning JC; Egli D; Costa R; Berbari N; Leibel RL; Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight 4:e123337 (2019).
    • Guo Y; Lei I; Tian S; Gao W; Hacer K; Li Y; Wang S; Liu L; Wang Z. Enhancing Cardiac Reprogramming by Suppressing Specific C-C Chemokine Signaling Pathways. bioRxiv :http://dx.doi.org/10.1101/522995 (2019).
    • Peng Q; Yue C; Chen ACH; Lee KC; Fong SW; Yueng WSB; Lee YL. Connexin 43 is involved in early differentiation of human embryonic stem cells. Differentiation 105:33-44 (2019).
    • Whitworth DJ; Limnios IJ; Gauthier M-E; Weeratunga P; Ovchinnikov DA; Baillie G; Grimmond SM; Graves JAM; Wolvetang EJ. Platypus Induced Pluripotent Stem Cells: the Unique Pluripotency Signature of a Monotreme . BioRXiv 43306: (2018)
    • Wang X; Sterr M; Burtscher I; CHen S; Hieronimus A; Machicao F; Staiger H; Haring H-U; Lederer G; Irmler M; Bechers J; de Angelis MH; Ray M; Wright CVE; Bakhti M; Lickert H. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors. Mol Metab 9:57-68 (2018).
    • Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules. Stem Cells International 2016:4304916 (2016).
    • Zhu S; Russ HA; Wang X; Zhang M; Ma T; Xu T; Tang S; Hebrok M; Deng S. Human pancreatic β-like cells converted from fibroblasts. Nature Commun 7:10080 (2016).
    • Zhu S; Wang H; Deng S. Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Nature Protocols 10, 959-973 (2015).
    • Liu G. No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts. J Stem Cell Res Ther 5:286 (2015).
    • Lee Y-L; Fong S-W; Chen ACH; Li T; Yue C; Lee C-L; Ng ENY; Yueng WSB; Lee K-F. Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation model. Hum Reprod 30:2614 (2015).
    • Higuchi S; Watanabe TM; Kawauchi K; Ichimura T; Fujita H. Culturing of mouse and human cells on soft substrates promot the expression of stem cell markers. J Biosci Bioeng 117:749 (2014).
    • Manoli DS; Subramanyam D; Carey C; Sudin E; Van Westerhuyzen J A; Bales KL; Belloch R; Shah NM. Generation of Induced Pluripotent Stem Cells from the Prairie Vole. PLoS One 7(5): e38119 (2012).
    • Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).
    • Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One 6(11): e27956.(2011).