RARA probe for ISH CE/IVD - Acute myeloid leukemia (AML)
Translocations involving the PML (promyelocytic leukemia portein, a.k.a. MYL) gene and the RARA (retinoic acid receptor alpha, a.k.a. RARα) gene are considered to be characteristic for acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia. Various fusion partners of RARA have been identified, however, in 95% of all APL cases, rearrangements involving the PML gene are detectable. This translocation t(15;17)(q24;q21) leads to a gene fusion of the PML and the RARA gene. The fusion is supposed to play a fundamental role in induction, development, and progression of APL. Since the PML/RARA fusion accounts for the response of these neoplasms to all-trans retinoic acid (ATRA) therapy and other conventional chemotherapy it is important to accurately distinguish between t(15;17) translocations and translocations involving other partners of RARA.
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