Anti-DSTYK antibody (200-250) {FITC}

Referencia NB-22-59644-100

embalaje : 100ug

Marca : Neo Biotech

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General Info

Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Bovine/Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DSTYK (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Information

Gene Symbol: DSTYK
Gene ID: 25778
Uniprot ID: DUSTY_HUMAN
Immunogen Region: 200-250
Immunogen: Synthetic peptide taken within amino acid region 200-250 on human Dual serine/threonine and tyrosine protein kinase protein (RIPK5).

Description

Tissue Specificity Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin.
Function Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
Protein Name Dual Serine/Threonine And Tyrosine Protein Kinase
Dusty Protein Kinase
Dusty Pk
Rip-Homologous Kinase
Receptor-Interacting Serine/Threonine-Protein Kinase 5
Sugen Kinase 496
Sgk496
Cellular Localisation Cytoplasm
Cell Membrane
Apical Cell Membrane
Basolateral Cell Membrane
Cell Junction
Detected At Apical Cell-Cell Junctions
Colocalized With Fgf Receptors To The Cell Membrane
Detected In Basolateral And Apical Membranes Of All Tubular Epithelia
Alternative Antibody Names Anti-Dual Serine/Threonine And Tyrosine Protein Kinase antibody
Anti-Dusty Protein Kinase antibody
Anti-Dusty Pk antibody
Anti-Rip-Homologous Kinase antibody
Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 5 antibody
Anti-Sugen Kinase 496 antibody
Anti-Sgk496 antibody
Anti-DSTYK antibody
Anti-KIAA0472 antibody
Anti-RIP5 antibody
Anti-RIPK5 antibody
Anti-SGK496 antibody
Anti-HDCMD38P antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance