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Anti-Laforin Antibody FL594 Conjugate

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Referencia 75-222-FL594

embalaje : 200uL

Contact local distributor :

Teléfono : +1 850 650 7790

Marca : Antibodies Incorporated

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Contact local distributor :

Teléfono : +1 850 650 7790

SKU: 75-222-FL594

Product Details

Target

Laforin

Target Description

Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) is encoded by the gene EPM2A. EPM2A is a member of the protein-tyrosine phosphatase family. EPM2A is a dual-specificity phosphatase that acts on complex carbohydrates to prevent glycogen hyperphosphorylation and the formation of insoluble aggregates. EPM2A promotes the ubiquitination of proteins involved in glycogen metabolism via its interactions with the E3 ubiquitin ligase NHLRC1/malin. EPM2A is expressed in the heart, skeletal muscle, kidney, pancreas, and the brain. Diseases associated with EPM2A include Myoclonic Epilepsy of Lafora, Myoclonic Epilepsy of Unverricht And Lundborg, and benign epilepsy with centrotemporal spikes.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N84/37

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

EPM2A

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-331 (full-length) of human Laforin (accession number O095278) produced recombinantly in E. Coli

Species Reactivity

Human

Antibody Registry ID

AB_2939818

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)

UniProt Details

UniProt (Human): O95278
UniProt (Immunogen Species): O95278

Anti-Laforin Antibody FL594 Conjugate

Referencia 75-222-FL594

Contact local distributor :

Marca : Antibodies Incorporated

Contact local distributor :

SKU: 75-222-FL594

Product Details

Bulk Order Anti-Laforin Antibody FL594 Conjugate

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