cGAMP [849214-04-6]
Referencia HY-12512-1mg
embalaje : 1mg
Marca : MedChemExpress
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
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cGAMP Estructura química
No. CAS : 849214-04-6
Based on 10 publication(s) in Google Scholar
Other Forms of cGAMP:
- cGAMP disodium In-stock
- cGAMP diammonium In-stock
Descripciòn |
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. |
IC50 & Target |
Endogenous Metabolite |
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In Vitro |
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Peso molecular |
674.41 |
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Fòrmula |
C20H24N10O13P2 |
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No. CAS |
849214-04-6 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5 |
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Envío | Room temperature in continental US; may vary elsewhere. |
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Almacenamiento |
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Solvente y solubilidad |
In Vitro:
H2O : 180 mg/mL (266.90 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureza y Documentación | |||||||||||||
Referencias |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 1.4828 mL | 7.4139 mL | 14.8278 mL | 37.0694 mL |
5 mM | 0.2966 mL | 1.4828 mL | 2.9656 mL | 7.4139 mL | |
10 mM | 0.1483 mL | 0.7414 mL | 1.4828 mL | 3.7069 mL | |
15 mM | 0.0989 mL | 0.4943 mL | 0.9885 mL | 2.4713 mL | |
20 mM | 0.0741 mL | 0.3707 mL | 0.7414 mL | 1.8535 mL | |
25 mM | 0.0593 mL | 0.2966 mL | 0.5931 mL | 1.4828 mL | |
30 mM | 0.0494 mL | 0.2471 mL | 0.4943 mL | 1.2356 mL | |
40 mM | 0.0371 mL | 0.1853 mL | 0.3707 mL | 0.9267 mL | |
50 mM | 0.0297 mL | 0.1483 mL | 0.2966 mL | 0.7414 mL | |
60 mM | 0.0247 mL | 0.1236 mL | 0.2471 mL | 0.6178 mL | |
80 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4634 mL | |
100 mM | 0.0148 mL | 0.0741 mL | 0.1483 mL | 0.3707 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
cGAMP Related Classifications
- Immunology/Inflammation
- STING