Conjugation | Biotin |
---|---|
Antigen | HLA-DR, DP, DQ |
Clone | IVA12 |
Isotype | IgG1, k |
Applications | FC |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Primary/Secondary | Primary |
Immunogen | Priess human B cell line |
Storage | 2-8°C |
Status | RUO |
Anti-HLA-DR, DP, DQ Biotin
Catalog #
Size
Lymphocytes gated PBMCs stained with anti-HLA-DR, DP, DQ (IVA12) Biotin (SA-PE) (RED); Lymphocytes gated PBMCs are used as FMO control (SA-PE only) (BLUE).
Description:
The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.