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> Ponasterone A [13408-56-5]

Ponasterone A [13408-56-5]

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Ponasterone A [13408-56-5]

Ponasterone A | Insect steroid hormone

CAS:
13408-56-5
Catalog Number:
10-1404
Activity:
Insect steroid hormone
Chemical Names:
(5β)-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-one
Alternate Name:
25-Deoxy-2-hydroxyecdysone; 25-deoxyecdysterone
Molecular Weight:
464.64
Molecular Formula:
C27H44O6
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (5 mg/ml with warming)
Physical Properties:
White solid
Purity:
>97% HPLC/TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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1 mg$50.00
5 mg$200.00
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Ponasterone A (13408-56-5) is a potent ecdysone agonist which elicits molting and metamorphosis in insects.1 Ponasterone A and related ecdysteroids have been used as activators in ecdysone-inducible mammalian expression systems.2,3 Has been used to create an inducible cell model for Huntingdon’s disease.4 Ecdysone analogs have been shown to display a strong antiapoptotic effect in mammalian cell lines thus ecdysone-based expression systems may not be suitable for analysis of apoptosis-related genes.5

References/Citations:

  1. Gonsalves et al. (2011), Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster; BMC Genomics 12 475
  2. Lafont and Dinan (2003), Practical uses for ecdysterones in mammals including humans: an update; J. Insect Sci. 3 7
  3. Saez et al. (2000), Identification of ligands and coligands for the ecdysone-regulated gene switch; Proc Nat. Acad. Sci USA 97 14512
  4. Chen et al. (2018), Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction; J. Biol. Sci. 293 15581
  5. Oehme et al. (2006), Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO; Cell Death Differ. 13 189
CAS:
13408-56-5
Catalog Number:
10-1404
Activity:
Insect steroid hormone
Chemical Names:
(5β)-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-one
Alternate Name:
25-Deoxy-2-hydroxyecdysone; 25-deoxyecdysterone
Molecular Weight:
464.64
Molecular Formula:
C27H44O6
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (5 mg/ml with warming)
Physical Properties:
White solid
Purity:
>97% HPLC/TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Ponasterone A (13408-56-5) is a potent ecdysone agonist which elicits molting and metamorphosis in insects.1 Ponasterone A and related ecdysteroids have been used as activators in ecdysone-inducible mammalian expression systems.2,3 Has been used to create an inducible cell model for Huntingdon’s disease.4 Ecdysone analogs have been shown to display a strong antiapoptotic effect in mammalian cell lines thus ecdysone-based expression systems may not be suitable for analysis of apoptosis-related genes.5

References/Citations:

  1. Gonsalves et al. (2011), Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster; BMC Genomics 12 475
  2. Lafont and Dinan (2003), Practical uses for ecdysterones in mammals including humans: an update; J. Insect Sci. 3 7
  3. Saez et al. (2000), Identification of ligands and coligands for the ecdysone-regulated gene switch; Proc Nat. Acad. Sci USA 97 14512
  4. Chen et al. (2018), Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction; J. Biol. Sci. 293 15581
  5. Oehme et al. (2006), Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO; Cell Death Differ. 13 189