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Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD58 (MEM-63) Biotin antibody (concentration in sample 1.67 μg/ml, Streptavidin APC).
CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.
| Subcellular location: | Cell membrane |
| BioGrid: | 107403. 13 interactions. |
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