Western Blot (Cell lysate)
Western blot analysis using CCR5 polyclonal antibody at 0.5 ug/mL on THP-1 whole cell lysates.
- Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CCR5.
Immunogen
A synthetic peptide corresponding to amino acids 6-20 of human CCR5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.25-0.5 ug/lmL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Western Blot (Cell lysate)
Western blot analysis using CCR5 polyclonal antibody at 0.5 ug/mL on THP-1 whole cell lysates. - Gene Info — CCR5
Entrez GeneID
1234Gene Name
CCR5
Gene Alias
CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Gene Description
chemokine (C-C motif) receptor 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
C-C chemokine receptor 5|C-C chemokine receptor type 5|CCR5 chemokine receptor|chemokine (C-C) receptor 5|chemokine receptor CCR5|chemr13
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Chemokine receptors: keys to AIDS pathogenesis?
Littman DR.
Cell 1998 May; 93(5):677.
Application：Flow Cyt, Human, Mouse, Moncytes, T cells.
- How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
Dimitrov DS.
Cell 1997 Dec; 91(6):721.
Application：Flow Cyt, Human, Mouse, T cells.
- Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
Doranz BJ, Lu ZH, Rucker J, Zhang TY, Sharron M, Cen YH, Wang ZX, Guo HH, Du JG, Accavitti MA, Doms RW, Peiper SC.
Journal of Virology 1997 Sep; 71(9):6305.
- Chemokine receptors: keys to AIDS pathogenesis?