Forskolin [66575-29-9]
Referência HY-15371-10mg
Tamanho : 10mg
Marca : MedChemExpress
Forskoline (Coleonol) est un activateur puissant de adénylate cyclase avec un IC50 de 41 nM et un EC50 de 0,5 μM pour l'adenylyl cyclase de type I. Forskoline est également un inducteur de la formation de AMPc intracellulaire. Forskoline induit la différenciation de divers types de cellules et active les récepteurs du prégnane X (PXR) et FXR. Forskoline exerce un effet inotrope sur le cœur et a des actions antiagrégantes et antihypertensives plaquettaires. Forskoline induit également l'autophagie.
Forskolin (Coleonol) ist ein potenter adenylate cyclase-Aktivator mit einer IC50 von 41 nM und einer EC50 von 0,5 μM für type I adenylyl cyclase. Forskolin ist auch ein Induktor der intrazellulären cAMP-Bildung. Forskolin induziert die Differenzierung verschiedener Zelltypen und aktiviert den pregnane X receptor (PXR) und FXR. Forskolin übt eine inotrope Wirkung auf das Herz aus und hat antiaggregationshemmende und blutdrucksenkende Wirkung auf Blutplättchen. Forskolin induziert auch autophagy.
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
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Forskolin Chemical Structure
CAS No. : 66575-29-9
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Based on 127 publication(s) in Google Scholar
Other Forms of Forskolin:
- Forskolin (Standard) Obtenir un devis
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Forskolin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Jan;120(1):321-331. [Abstract]
- The combination of Fsk and IBMX (Fsk-IBMX) inhibits the expression of cAMP related protein. The results of Western blot in glioma stem cells (GSCs).
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Forskolin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Jan;120(1):321-331. [Abstract]
- U0126 enhances the negative effect of Fsk-IBMX on the development of glioma stem cells (GSCs).
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Forskolin purchased from MedChemExpress. Usage Cited in: J Lipid Res. 2018 Feb;59(2):330-338. [Abstract]
- Forskolin (FSK) -stimulated dephsphorylation of HDAC5 is also inhibited by Thapsigargin (THA) treatment in primary hepatocytes.