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> Honokiol [35354-74-6]

Honokiol [35354-74-6]

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Referência 10-2311-10mg

Tamanho : 10mg

Marca : Focus Biomolecules

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Honokiol [35354-74-6]

Honokiol | SIRT3 activator

CAS:
35354-74-6
Catalog Number:
10-2311
Activity:
SIRT3 activator
Chemical Names:
3’,5-Diallyl-[1,1’-biphenyl]-2,4’-diol
Alternate Name:
NSC-293100
Molecular Weight:
266.34
Molecular Formula:
C18H18O2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% TLC/GC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size: Quantity 
10 mg$55.00
50 mg$220.00
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Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4

References/Citations:

  1. Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656
  2. Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326
  3. Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355
  4. Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740
CAS:
35354-74-6
Catalog Number:
10-2311
Activity:
SIRT3 activator
Chemical Names:
3’,5-Diallyl-[1,1’-biphenyl]-2,4’-diol
Alternate Name:
NSC-293100
Molecular Weight:
266.34
Molecular Formula:
C18H18O2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% TLC/GC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells.1 It reversed cardiac hypertrophy in mice1 and rescued myocardial and mitochondrial energetics in type 2 diabetic rats2. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage.3 It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.4

References/Citations:

  1. Pillai et al. (2015), Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3; Nat. Commun. 6 6656
  2. Kerr et al. (2020), Rescue of myocardial dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol; JCI Insight 5 e140326
  3. Ye et al. (2019), SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus; CNS Neurosci. 25 355
  4. Lee et al. (2022), Sirt3 Pharmacologically Promotes Insulin Sensitivity through PI3/AKT/mTOR and Their Downstream Pathway in Adipocytes; Int. J. Mol. Sci. 23 3740