Human Glutathione Peroxidase 3 (GPX3) activation kit by CRISPRa
Referência GA101937
Tamanho : 1kit
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Human Glutathione Peroxidase 3 (GPX3) activation kit by CRISPRa
SKU
GA101937
GPX3 CRISPRa kit - CRISPR gene activation of human glutathione peroxidase 3
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | GPX3 |
| Locus ID | 2878 |
| Components | GA101937G1, Glutathione Peroxidase 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101937G2, Glutathione Peroxidase 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101937G3, Glutathione Peroxidase 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001329790, NM_002084 |
| UniProt ID | P22352 |
| Synonyms | GPx-P; GSHPx-3; GSHPx-P |
| Summary | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN407758 | GPX3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.