Anti-HLA-ABC Unconjugated
Catalog #
Size
Lymphocyte-gated PBMCs stained with unconjugated HLA-ABC followed by goat anti-mouse IgG Alexa Fluor 488 (RED); Lymphocyte-gated PBMCs stained with unconjugated mouse IgG2a followed by goat anti-mouse IgG Alexa Fluor 488 (BLUE).
| Conjugation | Unconjugated |
|---|---|
| Antigen | HLA-ABC |
| Clone | W6/32 |
| Isotype | IgG2a, k |
| Applications | FC |
| Reactivity | Baboon, Cynomolgus monkey, Human, Rhesus |
| Host | Mouse |
| Clonality | Monoclonal |
| Primary/Secondary | Primary |
| Storage | 2-8°C |
| Status | RUO |
Description:
Clone W6/32 recognizes a cell surface 45 kD non-polymorphic epitope protein shared among products of the HLA-A, B, and C loci. HLA class I antigen associated with beta 2-microglobulin are expressed by all human nucleated cells and HLA-Class I down regulation occurs frequently in many cancers which might adversely affect the clinical course of cancer and the outcome of T-cell-based immunotherapy. HLA-Class I present specific foreign antigen to CD8+ T cells which play central role against infection, tumor and also generation of autoimmune diseases.
Clone W6/32 recognizes a cell surface 45 kD non-polymorphic epitope protein shared among products of the HLA-A, B, and C loci. HLA class I antigen associated with beta 2-microglobulin are expressed by all human nucleated cells and HLA-Class I down regulation occurs frequently in many cancers which might adversely affect the clinical course of cancer and the outcome of T-cell-based immunotherapy. HLA-Class I present specific foreign antigen to CD8+ T cells which play central role against infection, tumor and also generation of autoimmune diseases.