NGAL (LCN2) Human Gene Knockout Kit (CRISPR)
CAT#: KN207685LP
LCN2 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
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Specifications
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
| Donor DNA | Luciferase-Puro |
| Symbol | NGAL |
| Locus ID | 3934 |
| Components | KN207685G1, NGAL gRNA vector 1 in pCas-Guide CRISPR vector KN207685G2, NGAL gRNA vector 2 in pCas-Guide CRISPR vector KN207685LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_005564, N79823 |
| UniProt ID | P80188 |
| Synonyms | 24p3; MSFI; NGAL |
| Summary | This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN207685 | LCN2 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN207685BN | LCN2 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN207685RB | LCN2 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN407685 | LCN2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
| GA102668 | LCN2 CRISPRa kit - CRISPR gene activation of human lipocalin 2 | 1 657,00 EUR |