Recombinant Protein Human IL-2

Symansis' purified IL-2^hcx has O-linked oligosaccharides, shown by a drop in observed MW on SDS-PAGE after treatment with a glycosidase cocktail. Symansis' IL-2^hcx consists of 0-15% carbohydrate by weight.

Densitometry of protein isoforms visualised by 2-DE. Spot trains are normal in human proteins and highlight the presence of multiple isoforms which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein.

1D SDS-PAGE of Symansis' ^hcx protein before and after treatment with glycosidases to remove oligosaccharides. A drop in the observed MW after treatment indicates the presence of glycosylation.

1. Schrama D et al. (2005) Cancer Immunol. Immumother. 13:1-6

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